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Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study

Summary

This study analyzed over 4,000 research papers published between 2014 and 2024 about how oxidative stress damages kidneys in diabetic patients. Researchers found that China and the United States lead this research field, with increasing focus on natural compounds and traditional medicines that can reduce harmful reactive oxygen species. The findings suggest future treatments for diabetic kidney disease should target oxidative stress through both conventional drugs and natural antioxidant compounds derived from plants and fungi.

Background

Oxidative stress is recognized as a key pathogenic mechanism in diabetic nephropathy (DN). DN is one of the most common and severe complications of diabetes mellitus and a leading cause of end-stage renal disease. However, no comprehensive bibliometric analysis has been conducted on the relationship between oxidative stress and DN.

Objective

This study aims to systematically analyze relevant literature on oxidative stress and DN, identify research trends, assess current hotspots, and predict future directions using bibliometric analysis.

Results

A total of 4,076 publications were identified showing consistent upward trends. China (1,919 publications) and the United States (498 publications) are leading contributors. Top institutions include Jilin University and Central South University (69 publications each). Keyword analysis revealed oxidative stress as the most frequent term (3,683 occurrences), with emerging hotspots including gut microbiota, autophagy, and SGLT2 inhibitors. Seven research clusters were identified focusing on therapeutic prospects and molecular mechanisms.

Conclusion

Research on oxidative stress in DN has steadily increased since 2014, underscoring its pivotal role in DN pathogenesis. Future research should focus on molecular mechanisms of oxidative stress and explore therapeutic potential through natural compounds and novel drugs to develop new strategies for DN prevention and treatment.
  • Published in:Frontiers in Endocrinology,
  • Study Type:Bibliometric Analysis,
  • Source: 10.3389/fendo.2024.1451954, PMID: 39866738
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