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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

Summary

This study investigated whether two plant parasites that cause powdery and downy mildew could trigger asthma-like reactions in mice. Researchers found that extracts from these fungi induced immune responses similar to those caused by known allergens like ovalbumin, though somewhat weaker. The results suggest these organisms should be recognized as potential sources of respiratory allergies in humans. This finding may help explain some cases of allergies where the specific cause has been difficult to identify.

Background

Allergic conditions affect approximately 30% of the global population, with fungi accounting for about 6% of respiratory issues. Standard diagnostic tests often fail to identify specific allergens responsible for respiratory allergies. This study investigates whether two plant parasites, Podosphaera fusca and Peronospora ficariae, possess allergenic properties.

Objective

To assess the capacity of Podosphaera fusca and Peronospora ficariae to provoke inflammatory and asthmatic reactions in mouse models of both acute and chronic asthma through intranasal sensitization.

Results

Both P. fusca and P. ficariae induced significant production of all tested cytokines, increased specific IgE levels, and caused histological changes characteristic of asthma. Although weaker than ovalbumin, both organisms demonstrated proinflammatory and asthma-inducing capabilities in both acute and chronic models.

Conclusion

Podosphaera fusca and Peronospora ficariae possess proinflammatory and asthma-inducing potential, indicating they should be considered as potential inhalant allergens and expanded to the current list of fungal allergens recognized in respiratory allergies.
  • Published in:Cells,
  • Study Type:Experimental Animal Study,
  • Source: PMID: 40558541
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