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Anoectochilus roxburghii Extract Extends the Lifespan of Caenorhabditis elegans through Activating the daf-16/FoxO Pathway

Summary

Researchers studied a traditional Asian orchid plant (Anoectochilus roxburghii) and found it can extend the lifespan of laboratory worms by about 16% and help them resist stress from UV light and heat. The plant works by activating a specific genetic pathway that increases the worm’s natural antioxidant defenses, protecting cells from damage. These findings suggest the plant could potentially be developed into anti-aging products for humans.

Background

Aging is a complex biological process characterized by physiological decline and increased disease risk. Anoectochilus roxburghii is a rare orchid species traditionally used in Asian medicine for anti-inflammatory and antioxidant properties. Previous research indicates it is rich in flavonoids and polysaccharides that can scavenge free radicals and reduce oxidative stress.

Objective

This study investigated the anti-aging effects and mechanisms of A. roxburghii extract E (ARE) using Caenorhabditis elegans as a model organism. The research aimed to elucidate whether ARE can extend lifespan and enhance stress resistance through activation of the daf-16/FoxO signaling pathway.

Results

ARE extended C. elegans lifespan by 16.3%, reduced ROS and lipofuscin accumulation, and enhanced UV and heat stress resistance. ARE upregulated expression of daf-16, sod-3, and gst-4 genes and facilitated DAF-16 nuclear translocation. Lifespan extension was abolished in daf-16-deficient nematodes, confirming dependency on the daf-16/FoxO pathway.

Conclusion

ARE demonstrates anti-aging effects on C. elegans through activation of the daf-16/FoxO signaling pathway, promoting nuclear translocation of DAF-16 and upregulating downstream antioxidant enzymes. These findings provide a theoretical foundation for developing anti-aging health products based on A. roxburghii with potential applications for human longevity and stress resilience.
  • Published in:Antioxidants (Basel),
  • Study Type:In vivo experimental study,
  • Source: PMC11351832; PMID: 39199191; 10.3390/antiox13080945
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