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Assessment of the Antitumor Activity of Green Biosynthesized Zinc Nanoparticles as Therapeutic Agent Against Renal Cancer in Rats

Summary

Researchers created tiny zinc nanoparticles using an edible white mushroom through an environmentally friendly process. When tested in rats with kidney cancer, these nanoparticles significantly reduced tumor markers, protected kidney cells from oxidative damage, and triggered cancer cell death. The treatment improved kidney function and showed no toxic effects, suggesting it could be a promising new therapy for kidney cancer.

Background

Zinc nanoparticles (Zn-NPs) have shown potential as cancer therapy agents. Green synthesis using microorganisms presents an eco-friendly approach to nanoparticle production. This study investigated biosynthesized Zn-NPs as a therapeutic agent against kidney cancer induced by ferric-nitrilotriacetate (Fe-NTA) in rats.

Objective

To assess the antitumor activity of green biosynthesized zinc nanoparticles as a therapeutic agent against renal cancer induced by Fe-NTA in rats by evaluating biochemical, molecular, and histopathological markers.

Results

Zn-NPs treatment significantly suppressed renal oxidative stress, restored antioxidant enzyme activities, reduced lipid peroxidation, and improved renal toxicity markers. Tumor markers CEA showed significant improvement, caspase-3 levels increased, and DNA fragmentation decreased in treated groups. Histopathological examination confirmed amelioration of kidney tissue damage in Zn-NPs treated animals.

Conclusion

Microbial synthesized Zn-NPs possess potent antitumor activity against Fe-NTA-induced renal toxicity and carcinogenesis through antioxidant and pro-apoptotic mechanisms. The results suggest Zn-NPs as a promising therapeutic agent for renal cancer and warrant further clinical evaluation.
  • Published in:Biological Trace Element Research,
  • Study Type:In vivo Animal Study,
  • Source: PMID: 35083709, DOI: 10.1007/s12011-022-03126-5
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