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Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy

Summary

A new supplement formula combining Chaga mushroom extract, Coenzyme Q10, and alpha-lipoic acid was tested on nerve cells in the laboratory. The formula increased the cells’ energy production and protected them from harmful oxidative stress. This could potentially help people with conditions like fibromyalgia and neurodegenerative diseases that involve mitochondrial dysfunction.

Background

Mitochondrial dysfunction is associated with aging and age-related diseases including neurodegenerative disorders and fibromyalgia. Bioactive compounds such as coenzyme Q10, alpha-lipoic acid, and medicinal mushroom extracts have demonstrated potential for supporting mitochondrial health and reducing oxidative stress.

Objective

To evaluate the impact of a novel antioxidant formulation (RP-25) containing CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress in neuronal cells using NMR-based metabolomics and UHPLC-HRMS analytical techniques.

Results

RP-25 treatment significantly increased ATP concentrations (0.05 mM treated vs 0.01 mM control), enhanced metabolic pathways including amino acid biosynthesis and oxidative phosphorylation, and increased levels of glutamate, tyrosine, and proline. The formulation stabilized mitochondrial membrane potential and demonstrated antioxidant activity under oxidative stress conditions induced by hydrogen peroxide.

Conclusion

RP-25 demonstrated biological activity in mitigating mitochondrial dysfunction and oxidative stress in neuronal cells. The formulation’s synergistic combination of Chaga extract, CoQ10, and alpha-lipoic acid showed potential therapeutic implications for neuronal diseases associated with dysfunctional mitochondria, including fibromyalgia and neurodegenerative disorders.
  • Published in:Antioxidants (Basel),
  • Study Type:In vitro Experimental Study,
  • Source: 40563385
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