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Armillaria mellea Mycelia Alleviate PM2.5-Induced Pulmonary Inflammation in Murine Models

Summary

This study found that Armillaria mellea mushroom mycelia can help protect lungs from damage caused by PM2.5 air pollution. When tested in both laboratory cells and mice, the mushroom extract reduced inflammatory responses and restored healthy lung function. The protective effects work by reducing harmful inflammatory molecules and blocking inflammatory signaling pathways. These findings suggest A. mellea could be developed into a natural supplement to help protect respiratory health in areas with poor air quality.

Background

PM2.5 particulate matter significantly contributes to respiratory inflammation and disease. Armillaria mellea is recognized for medicinal properties including immunomodulatory and anti-inflammatory effects. However, its efficacy against PM2.5-induced inflammation remains unclear.

Objective

To investigate whether Armillaria mellea mycelia could mitigate PM2.5-induced respiratory inflammation and assess the underlying molecular mechanisms in both in vitro and in vivo models.

Results

A. mellea mycelia significantly reduced PM2.5-induced NO production and NF-κB activation in macrophages in a concentration-dependent manner. Treatment suppressed expression of inflammatory mediators iNOS and COX-2, and reduced proinflammatory cytokines IL-1β and TNF-α. In murine models, A. mellea mycelia mitigated lung inflammation, reduced cytokine secretion, and restored normal lung tissue architecture.

Conclusion

A. mellea mycelia demonstrated potent antioxidant and anti-inflammatory properties against PM2.5-induced respiratory inflammation through NF-κB pathway suppression. These findings highlight the therapeutic potential of A. mellea for developing interventions to improve respiratory health following PM2.5 exposure.
  • Published in:Antioxidants (Basel),
  • Study Type:Experimental Study (in vitro and in vivo),
  • Source: PMID: 39594523, DOI: 10.3390/antiox13111381
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