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The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy

Summary

Researchers found that date palm roots from disease-resistant varieties contain a special compound called 3,3′,4,5,5′-pentahydroxy-trans-stilbene that acts as a natural antioxidant and anti-aging agent. This compound can protect aging skin cells by activating the proteasome, which is like the cell’s recycling system that removes damaged proteins. The findings suggest this natural compound could potentially help slow down skin aging and protect against age-related diseases.

Background

Date palm (Phoenix dactylifera L.) is economically important in Morocco but suffers from Bayoud disease caused by Fusarium oxysporum f. sp Albidinis. Previous research identified phenolic compounds as contributors to disease resistance. This study investigates stilbene compounds in resistant date palm varieties and their potential anti-aging properties.

Objective

To identify and characterize bioactive stilbene compounds in resistant date palm varieties and evaluate their antioxidant properties, proteasome activation capacity, and protective effects against oxidative damage in aging human dermal fibroblasts.

Results

The resistant TAAR variety accumulated significantly higher levels of 3,3′,4,5,5′-pentahydroxy-trans-stilbene compared to sensitive varieties. PHS demonstrated strong antioxidant activity, inhibited mushroom tyrosinase activity, and activated the 20S proteasome in aged fibroblasts while protecting against hypochlorite-induced proteasome damage. The compound also showed antifungal effects against Fusarium oxysporum.

Conclusion

3,3′,4,5,5′-pentahydroxy-trans-stilbene appears to be a constitutive defense compound in resistant Phoenix dactylifera L. and demonstrates potential as an anti-aging agent through proteasome activation and preservation, suggesting therapeutic applications for proteasome-related diseases and aging-related conditions.
  • Published in:Cells,
  • Study Type:Laboratory/Experimental Research,
  • Source: PMID: 36611864, DOI: 10.3390/cells12010071
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