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A case of corneal infection with Clonostachys rosea

Summary

A 53-year-old patient developed a serious eye infection caused by a fungus called Clonostachys rosea, which had never been reported before as causing eye disease. The infection caused a painful ulcer on the cornea (the clear front part of the eye). Doctors treated the infection with antifungal medications applied as eye drops and taken as tablets, and the patient recovered well within about a month.

Background

Fungal keratitis poses a significant threat to vision, with Fusarium, Aspergillus, and Candida being the most prevalent causative strains. No cases of corneal infection attributed to Clonostachys rosea have been previously reported in the literature.

Objective

To describe the first reported case of corneal infection caused by Clonostachys rosea and outline its development, clinical presentation, and treatment to enhance clinical comprehension and management of similar cases.

Results

Fungal growth was confirmed through corneal scrape culture and subsequently identified as Clonostachys rosea through DNA sequencing (GenBank No. MN889471.1, 100% similarity). After treatment with natamycin, fluconazole eye drops, and oral terbinafine, the patient showed significant improvement with ulcer lesions forming scars within 35 days.

Conclusion

This case represents the first reported corneal infection caused by Clonostachys rosea. The infection responded well to antifungal treatment with natamycin, fluconazole, and terbinafine, resulting in scar tissue formation and recovery within one month.
  • Published in:BMC Infectious Diseases,
  • Study Type:Case Report,
  • Source: PMID: 40240986, DOI: 10.1186/s12879-025-10903-9
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