Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients
- Author: mycolabadmin
- 5/8/2025
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Summary
This case report describes two patients with weakened immune systems who developed serious fungal skin infections caused by a rare mold called Medicopsis romeroi. Both patients underwent multiple surgeries and required extended antifungal medication treatment lasting months to years. The study demonstrates that successful treatment requires a combination approach including surgical removal of infected tissue, adjustment of immunosuppressive medications, and prolonged antifungal therapy.
Background
Medicopsis romeroi is a rare brown-pigmented mold causing phaeohyphomycosis, a subcutaneous or soft tissue fungal infection. The infection primarily affects immunocompromised patients such as solid organ transplant recipients and may involve multiple tissues including skin, bones, and sinuses.
Objective
To describe two cases of extensive and persistent infection caused by M. romeroi in immunocompromised patients and provide clinical practice recommendations for optimal diagnosis and treatment.
Results
Both patients presented with extensive cutaneous lesions requiring multiple surgical interventions combined with long-term antifungal therapy. Case 1 involved multiple lesions treated with voriconazole for seven months achieving remission. Case 2 required nearly two years of posaconazole therapy and multiple surgical debridements before complete remission was achieved.
Conclusion
Optimal treatment of M. romeroi infections requires combination therapy including surgical excision of lesions, careful adjustment of immunosuppressive therapy, and prolonged antifungal therapy. Early biopsy and fungal culture are recommended for prompt diagnosis. Incision and drainage alone is insufficient; complete surgical excision is necessary to prevent recurrence.
- Published in:Medical Mycology Case Reports,
- Study Type:Case Series,
- Source: 10.1016/j.mmcr.2025.100706, PMID: 40487190