Genome Sequencing Illustrates the Genetic Basis of the Pharmacological Properties of Gloeostereum incarnatum
- Author: mycolabadmin
- 2019-03-01
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Summary
Scientists have sequenced the complete genome of Gloeostereum incarnatum, an edible medicinal mushroom commonly found in Asia. This research helps us understand how this mushroom produces beneficial compounds that have health-promoting properties. Impact on everyday life:
– Could lead to more efficient production of natural medicines and supplements
– May help develop new antibacterial treatments from mushroom compounds
– Provides insights for improving mushroom cultivation techniques
– Could enable development of enhanced mushroom varieties with higher medicinal properties
– Advances our understanding of how fungi produce beneficial compounds that can improve human health
Background
Gloeostereum incarnatum is a precious edible mushroom widely grown in Asia and known for its medicinal properties including antioxidant, immunomodulatory, anti-inflammatory, anti-proliferative and antibacterial effects. Recent studies have shown that sesquiterpenes and polysaccharides are the main bioactive compounds underlying its beneficial effects.
Objective
This study aimed to present a high-quality reference genome for G. incarnatum and identify relevant functional genes, gene clusters, and signaling pathways associated with its saprophytic lifestyle and pharmaceutical properties, with specific focus on terpene biosynthesis, cytochrome P450 enzyme biosynthesis, and polysaccharide production.
Results
The assembled G. incarnatum genome was 38.67 Mbp with an N50 of 3.5 Mbp, encoding 15,251 proteins. The genome contained 311 CAZymes, 145 cytochrome P450 proteins, and 65 secondary metabolite gene clusters including 15 terpene synthases. Two terpenoid-associated gene clusters were identified containing sesterterpenoid synthase genes adjacent to cytochrome P450 enzyme genes. Transcriptomic analysis showed terpenoid biosynthesis genes were generally upregulated in mycelium while polysaccharide biosynthesis genes were upregulated in the fruiting body.
Conclusion
This study presents the first complete genome sequence from the Cyphellaceae family and provides insights into the genetic basis of G. incarnatum’s medicinal properties. The identification of key genes and gene clusters involved in bioactive compound production lays a framework for future characterization of pharmacologically active compounds and potential industrial applications.
- Published in:Genes (Basel),
- Study Type:Genomic Analysis,
- Source: 10.3390/genes10030188