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Apoptotic Effect of Extract from Medicinal Mushroom from Taiwan Taiwanofungus salmoneus (Higher Basidiomycetes) Mycelium Combined with or without Cisplatin on Hepatocellular Carcinoma Cells

Summary

This research investigated how an extract from the medicinal mushroom Taiwanofungus salmoneus could enhance the effectiveness of chemotherapy drugs in treating liver cancer. When combined with the chemotherapy drug cisplatin, the mushroom extract showed promising results in killing cancer cells more effectively than either treatment alone. Impacts on everyday life: • Offers potential for more effective liver cancer treatments with fewer side effects • Demonstrates the value of combining natural medicines with conventional treatments • Shows promise for developing new cancer therapies using medicinal mushrooms • Could lead to more affordable cancer treatment options • Highlights the importance of natural product research in modern medicine

Background

Hepatocellular carcinoma is a cancer with high mortality rates, making effective therapies crucial. Recent research has shown that combining anticancer agents with natural products can effectively increase cancer cell apoptosis.

Objective

To investigate the apoptotic effect and possible mechanism of the ethanol extract from Taiwanofungus salmoneus mycelium (TsE) alone or in combination with cisplatin in SK-Hep-1 cells.

Results

The study found that TsE inhibited SK-Hep-1 cell proliferation, with enhanced effects when combined with cisplatin. The combination treatment increased DNA damage and cell cycle interruption. It significantly induced cell apoptosis and upregulated the expression of caspases 3, 8, and 9.

Conclusion

TsE combined with cisplatin effectively inhibits cell proliferation by elevating sub-G1 phase, inducing DNA damage, activating caspases 3, 8, and 9 activities, and triggering cell apoptosis. The findings suggest that TsE could serve as a potential adjuvant chemotherapeutic agent.
  • Published in:International Journal of Medicinal Mushrooms,
  • Study Type:Laboratory Study,
  • Source: 10.1615/IntJMedMushrooms.v17.i6.70
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