MYCOLab Ai Logo - gold and army green

Anti-inflammatory Activity of Mycelial Extracts from Medicinal Mushrooms

Summary

This research investigated how extracts from medicinal mushrooms can reduce inflammation in cells. Scientists tested different extracts from five medicinal mushrooms and found that many of them could effectively reduce inflammatory responses, with Ganoderma lucidum showing the strongest effects. Impacts on everyday life: • Provides scientific support for traditional use of medicinal mushrooms • Suggests new natural options for treating inflammatory conditions • Could lead to development of anti-inflammatory supplements • Offers potential alternatives to synthetic anti-inflammatory drugs • May help people manage chronic inflammation-related conditions

Background

Medicinal mushrooms have been essential components of traditional Chinese herbal medicines for thousands of years, providing protection against various health conditions. However, the specific components responsible for their anti-inflammatory properties have not been fully investigated.

Objective

To investigate the anti-inflammatory activity of different solvent extracts (n-hexane, chloroform, ethyl acetate, and methanol) from the mycelia of 5 commercially available medicinal mushrooms: Cephalosporium sinensis, Cordyceps mortierella, Hericium erinaceus, Ganoderma lucidum, and Armillaria mellea.

Results

Multiple extracts from C. sinensis, C. mortierella, and G. lucidum showed dose-dependent inhibition of LPS-induced NO production. Chloroform extracts from H. erinaceus and A. mellea, and ethyl acetate extracts from A. mellea also demonstrated inhibitory effects. The chloroform extract from G. lucidum proved most effective, with the lowest half maximal inhibitory concentration (64.09 ± 6.29 μg/mL) of LPS-induced NO production.

Conclusion

The extracts from medicinal mushrooms demonstrated significant anti-inflammatory activity through inhibition of NO generation. These findings suggest potential therapeutic applications for various inflammation-related diseases.
  • Published in:International Journal of Medicinal Mushrooms,
  • Study Type:Laboratory Study,
  • Source: PMID: 25271860
Scroll to Top