Weaving of Bacterial Cellulose by the BCS Secretion Systems
- Author: mycolabadmin
- 2021-10-11
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Summary
This research examines how bacteria produce and secrete cellulose, which is the most abundant biological material on Earth. While we typically associate cellulose with plants, many bacteria can also make this important molecule to help them survive and thrive in different environments. The study reveals the complex molecular machinery that bacteria use to manufacture and export cellulose, which they use to form protective biofilm communities and interact with their surroundings.
Impacts on everyday life:
• Understanding bacterial cellulose production could lead to more sustainable and eco-friendly materials for medical applications, food packaging, and electronics
• This knowledge helps explain how harmful bacteria form antibiotic-resistant biofilms in infections and on medical devices
• The findings could help develop new strategies to either promote beneficial bacterial growth (like in probiotic foods) or prevent harmful bacterial colonization
• This research advances our ability to engineer bacteria to produce custom-designed cellulose materials with specific properties
• The insights gained could lead to improved treatments for biofilm-related infections and better wound dressing materials
Background
Cellulose is the most abundant biological compound on Earth and while it is predominantly found in plants, it is also a key extracellular matrix component in many diverse bacterial species. While bacterial cellulose was first described in the 19th century, recent structural studies have provided insights into how the cellulose synthase BcsA, assisted by its inner-membrane partner BcsB, senses c-di-GMP to simultaneously polymerize and extrude the nascent polysaccharide across the bacterial inner membrane.
Objective
This review aims to provide a detailed overview of the current mechanistic knowledge on bacterial cellulose secretion with focus on the structure, assembly and cooperativity of Bcs secretion system components.
Results
The review reveals that bacterial cellulose can be produced by several distinct types of cellulose secretion systems featuring multiple accessory subunits often indispensable for polysaccharide production. Recent years have marked significant progress in understanding not only cellulose polymerization but also bacterial signaling, secretion system assembly, biofilm formation and host tissue colonization. The review details the structural and functional roles of various Bcs components including BcsA, BcsB, BcsC, BcsD, BcsE, BcsF, BcsG, BcsH, BcsQ, BcsR and BcsZ.
Conclusion
Understanding bacterial cellulose secretion requires viewing Bcs assemblies as highly cooperative secretion nanomachines with multilevel control of their expression, assembly, cellular and biofilm localization, synthase activation and product modifications. Further research is needed to fully understand cellulose crystallinity determinants, c-di-GMP-dependent activation mechanisms, and interactions with other extracellular matrix components.
- Published in:FEMS Microbiology Reviews,
- Study Type:Review,
- Source: 10.1093/femsre/fuab051