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Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats

Summary

This research investigated how an extract from the medicinal mushroom Agaricus brasiliensis could help treat nerve pain caused by diabetes. The study found that this mushroom extract effectively reduced pain and inflammation while helping control blood sugar in diabetic rats. Impact on everyday life: • Could provide a natural alternative for managing diabetic nerve pain • May help reduce reliance on conventional pain medications with side effects • Demonstrates potential of mushrooms as therapeutic agents • Could improve quality of life for diabetes patients • Suggests new directions for developing natural pain treatments

Background

Diabetic neuropathy is the most common secondary complication of diabetes mellitus, characterized by slowing nerve conduction velocity, elevated pain, sensory loss, and nerve fiber degeneration. Current treatments like antidepressants, anticonvulsants, and painkillers provide limited relief and have significant side effects. There is a need for new therapeutic interventions targeting primary mechanisms of nerve damage.

Objective

To evaluate the neuroprotective effect of Agaricus brasiliensis (AbS) against streptozotocin (STZ)-induced diabetic neuropathic pain in laboratory rats by assessing various behavioral and biochemical parameters.

Results

Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight and pain thresholds, while decreasing serum glucose, LPO, NO levels, and inflammatory markers TNF-α and IL-1β compared to untreated diabetic rats. The effects were dose and time dependent. AbS also restored Na-K-ATPase activity and SOD levels in sciatic nerves.

Conclusion

Agaricus brasiliensis demonstrated significant pain relief in peripheral diabetic neuropathy through multiple mechanisms including antioxidant, anti-inflammatory and hypoglycemic effects. This suggests potential clinical benefit for managing diabetic neuropathy.
  • Published in:Evidence-based Complementary and Alternative Medicine,
  • Study Type:Experimental Animal Study,
  • Source: 10.1155/2014/679259
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