Anti-microorganism, Anti-tumor, and Immune Activities of a Novel Polysaccharide Isolated from Tricholoma matsutake
- Author: mycolabadmin
- 2013-07-01
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Summary
Scientists discovered that a sugar-based compound (polysaccharide) extracted from the matsutake mushroom has multiple beneficial health effects. This natural compound can fight harmful bacteria, help combat tumor growth, and boost the immune system. Impact on everyday life:
– Could lead to new natural antibiotics for treating infections
– May provide alternative or complementary cancer treatments
– Demonstrates the value of traditional medicinal mushrooms in modern medicine
– Offers potential for developing natural immune system boosters
– Shows promise for creating new pharmaceutical products from natural sources
Background
Fungal polysaccharides are active organic compounds found in fruiting bodies, mycelium, and fermentation broth of edible and medicinal fungi. They have emerged as an important class of bioactive natural products, exhibiting various biological activities including anti-tumor, immunostimulation, and anti-oxidation properties. Tricholoma matsutake is a widely distributed fungus in Asian countries that has been traditionally used both as food and medicine.
Objective
To investigate the anti-microorganism, anti-tumor, and immune activities of a novel polysaccharide (TMP-A) isolated from Tricholoma matsutake.
Results
TMP-A showed strongest antibacterial activity against Micrococcus lysodeikticus with an inhibition zone diameter of 24.38 ± 1.19 mm at 20 mg/ml concentration. It demonstrated no antifungal activity. For anti-tumor effects, TMP-A at 80 mg/kg showed the highest tumor inhibition rate of 68.422%. The compound significantly promoted lymphocyte proliferation at 50-200 μg/mL and macrophage stimulation at 100-400 μg/mL in vitro.
Conclusion
The purified polysaccharide TMP-A from Tricholoma matsutake demonstrates potential as a natural broad-spectrum antimicrobial agent with significant anti-tumor and immunomodulation properties. Its anti-tumor activity appears to work through stimulation of cell-mediated immune responses.
- Published in:Pharmacognosy Magazine,
- Study Type:Laboratory Study,
- Source: 10.4103/0973-1296.113278