Polyellisin, a Novel Polyketide from Cultures of the Basidiomycete Polyporus ellisii
- Author: mycolabadmin
- 2018-09-10
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Summary
Scientists discovered a new chemical compound called polyellisin from an edible mushroom species that grows in China. This discovery is significant because it represents a completely new type of natural molecule with potential anti-inflammatory properties. The research demonstrates how edible fungi can be sources of beneficial compounds.
Impacts on everyday life:
• Identifies new potential sources of anti-inflammatory compounds from food sources
• Advances our understanding of beneficial compounds in edible mushrooms
• Provides new chemical tools for developing anti-inflammatory medications
• Highlights the importance of preserving fungal biodiversity
• Demonstrates the ongoing value of investigating traditional food sources for medical compounds
Background
The basidiomycete Polyporus ellisii, belonging to the family Polyporaceae, is widely distributed in the Yunnan and Sichuan Provinces of China. Its young fruiting body is used as a popular and delicious food in southwestern China, Japan and Korea. Previous chemical investigations of this species have identified biologically active cerebrosides from its fruiting bodies, as well as ergosterols and sesquiterpenoids from its cultures.
Objective
To isolate and characterize novel bioactive compounds from cultures of the fungus Polyporus ellisii, with a focus on identifying structurally interesting and biologically active natural products.
Results
A novel polyketide named polyellisin was isolated and characterized. The compound possesses a tricyclic system sharing a spiroketal carbon, with molecular formula C20H28O6. While it showed no significant cytotoxicity against tested cancer cell lines (IC50 > 40 μM), it demonstrated NO production inhibitory activity with an IC50 value of 17.2 μM.
Conclusion
The chemical investigation of P. ellisii led to the isolation of polyellisin, a novel polyketide with an unprecedented tricyclic system. While the compound showed limited cytotoxicity, its NO production inhibitory activity suggests potential anti-inflammatory properties that warrant further investigation.
- Published in:RSC Advances,
- Study Type:Chemical Isolation and Characterization,
- Source: 10.1039/c8ra06544f