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Characterization and Anti-inflammatory Potential of an Exopolysaccharide from Submerged Mycelial Culture of Schizophyllum commune

Summary

This research examined a complex sugar molecule produced by the fungus Schizophyllum commune and found it has powerful anti-inflammatory properties. The study provides detailed analysis of the molecule’s structure and demonstrates its potential medical applications. Impacts on everyday life: – Could lead to new natural anti-inflammatory medications with fewer side effects – May help develop treatments for inflammatory diseases and cancer – Demonstrates potential for using fungi to produce beneficial medical compounds – Could improve our understanding of how natural compounds affect inflammation – May lead to new food additives or supplements with health benefits

Background

Mushroom polysaccharides have attracted attention in food and pharmacology fields due to their biological activities. Schizophyllum commune is a widely distributed fungus that produces exopolysaccharides (EPS) with potential therapeutic properties. These EPS have industrial applications as emulsifiers, stabilizers, binders, and gelling agents, while also showing promising immune modulating and anti-cancer effects.

Objective

To characterize the structure and evaluate the anti-inflammatory activity of an exopolysaccharide isolated from submerged mycelial fermentation of S. commune.

Results

The isolated exopolysaccharide was a homogeneous protein-bound heteropolysaccharide with molecular weight of 2,900 kDa. It contained a β-(1→3) glycosidic backbone with (1→4)- and (1→6)-glycosidic side chains, and high glucose content. The exopolysaccharide significantly inhibited lipopolysaccharides-induced iNOS expression levels in cells in a dose-dependent manner and decreased NO and 5-LOX production.

Conclusion

The exopolysaccharide from S. commune demonstrated significant anti-inflammatory effects, suggesting potential applications as an effective anti-inflammatory agent for NO-related disorders such as inflammation and cancer.
  • Published in:Frontiers in Pharmacology,
  • Study Type:Laboratory Research,
  • Source: 10.3389/fphar.2017.00252
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