Inhibition of Protein Glycation by Tiger Milk Mushroom [Lignosus rhinocerus (Cooke) Ryvarden] and Search for Potential Anti-Diabetic Activity-Related Metabolic Pathways by Genomic and Transcriptomic Data Mining
- Author: mycolabadmin
- 2018-02-14
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Summary
This research examined how the tiger milk mushroom could help prevent complications from diabetes by stopping harmful protein modifications called glycation. The study found that certain compounds in the mushroom are very effective at preventing these damaging changes, potentially helping diabetic patients avoid serious complications.
Key impacts on everyday life:
– Could provide a natural supplement option for managing diabetes complications
– Demonstrates the scientific basis for traditional medicinal mushroom use
– Opens possibilities for new anti-diabetic drug development from natural sources
– Shows how modern science can validate traditional medicine
– Offers potential preventive approach for diabetes-related health issues
Background
The tiger milk mushroom (Lignosus rhinocerus) is an important medicinal mushroom traditionally used to treat various health conditions including wounds, fever, cough, asthma, and cancer. Natural compounds with anti-glycation properties are of interest for reducing diabetic complications. Previous studies showed L. rhinocerus exhibits antioxidant properties, suggesting potential anti-glycation effects.
Objective
To investigate the anti-glycation potential of L. rhinocerus through genome-transcriptome analysis and in vitro studies, and identify molecular pathways and compounds that may contribute to anti-diabetic properties.
Results
Genome analysis identified transcripts related to carotenoid/terpenoid biosynthesis, abscisic acid production, and antioxidant enzymes like superoxide dismutases. The medium-molecular-weight fraction showed potent inhibition of advanced glycation end-product formation with an IC50 of 0.001 mg/ml, 520 times lower than aminoguanidine control. This fraction also exhibited strong superoxide radical scavenging activity correlated with its anti-glycation effects.
Conclusion
L. rhinocerus contains compounds with significant anti-glycation potential, particularly in its medium-molecular-weight fraction. The anti-glycation activity appears linked to potent superoxide radical scavenging properties. The identified molecular pathways and bioactive compounds suggest L. rhinocerus has promise for development as an anti-diabetic agent for preventing glycation-related complications.
- Published in:Frontiers in Pharmacology,
- Study Type:Laboratory Research,
- Source: 10.3389/fphar.2018.00103