MYCOLab Ai Logo - gold and army green

Agaricus brasiliensis Mushroom Protects Against Sepsis by Alleviating Oxidative and Inflammatory Response

Summary

This research investigated how an extract from the Agaricus brasiliensis mushroom could help protect against sepsis, a life-threatening condition caused by the body’s extreme response to infection. The study found that the mushroom extract helped mice survive sepsis by reducing inflammation and protecting cells from oxidative damage. Impacts on everyday life: – Demonstrates potential for natural medicines from mushrooms to treat serious conditions – Offers a possible new treatment option for sepsis, which currently has limited therapies – Shows how natural antioxidants can help protect against cellular damage – Highlights the medicinal value of mushrooms as functional foods – Suggests new ways to boost the body’s natural immune defenses

Background

Sepsis leads to about 6 million deaths per year worldwide and is considered the main cause of death in intensive care units. It is characterized by a dysregulated immune response to infection accompanied by an imbalance between pro-oxidant and antioxidant defenses, which can cause lipid peroxidation, DNA damage, mitochondrial dysfunction, and multiple organ failure.

Objective

To investigate the immunomodulatory and antioxidant effects of Agaricus brasiliensis aqueous extract in the cecal ligation and puncture (CLP) sepsis model.

Results

A. brasiliensis extract improved survival of septic mice, reduced systemic inflammatory response and improved bacterial clearance. The extract decreased oxidative stress markers in serum, peritoneal cavity, heart and liver of septic animals. It also reduced ROS production both in vitro and in vivo, and prevented tert-Butyl hydroperoxide-induced DNA damage in peripheral blood mononuclear cells from healthy donors.

Conclusion

The pretreatment with A. brasiliensis aqueous extract increased the survival of septic animals through immunomodulatory and antioxidant protective effects. The extract controlled leukocyte recruitment, reduced inflammatory cytokines and oxidative stress markers while increasing antioxidant defenses.
  • Published in:Frontiers in Immunology,
  • Study Type:Experimental Animal Study,
  • Source: 10.3389/fimmu.2020.01238
Scroll to Top