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The Characteristic, Antioxidative and Multiple Organ Protective Effects of Acidic-Extractable Mycelium Polysaccharides by Pleurotus eryngii var. tuoliensis on High-Fat Emulsion Induced-Hypertriglyceridemic Mice

Summary

This research examined how compounds extracted from an edible mushroom could help treat high blood fat levels and protect vital organs from damage. The study found that mushroom-derived polysaccharides could effectively lower harmful blood fats while protecting the liver, heart, kidney and spleen from damage through their antioxidant properties. Impacts on everyday life: – Provides a natural alternative to conventional medications for managing high blood fat levels – Offers potential new functional food ingredients from common edible mushrooms – Demonstrates how mushrooms could be used to prevent organ damage from metabolic disorders – Shows promise for developing safer treatments with fewer side effects – Highlights the potential health benefits of including medicinal mushrooms in the diet

Background

Hypertriglyceridemia (HTG) is a common lipid metabolic disorder disease characterized by fasting blood triglyceride levels over 150 mg/dL. It can be caused by genetic factors and external factors like obesity, excess alcohol intake, metabolic syndrome, and insulin resistance. HTG can lead to complications including cardiovascular diseases, diabetes, neuropathy, and organ insufficiency. Current treatments have side effects, creating a need for safe and effective natural alternatives.

Objective

To investigate the antioxidant and multiple organ protective effects of acid-extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on high-fat emulsion (HFE) induced hypertriglyceridemic mice, and to characterize the structure of these polysaccharides.

Results

Ac-MPS showed potential ability to relieve hypertriglyceridemia by decreasing levels of TG, TC, LDL-C and elevating HDL-C in serum. It increased activities of antioxidant enzymes (SOD, GSH-Px, CAT, T-AOC) while reducing MDA and LPO contents in liver, heart, kidney and spleen. Histopathological observations showed Ac-MPS could alleviate organ damage. The polysaccharides had a molecular weight of 2.712 × 105Da and contained glucose as the predominant monosaccharide.

Conclusion

The Ac-MPS extracted from P. eryngii var. tuoliensis demonstrated significant antioxidant activities and protective effects against HTG-induced organ damage. The findings suggest Ac-MPS could be used as a natural functional food ingredient for preventing and alleviating severe hypertriglyceridemia and its complications.
  • Published in:Scientific Reports,
  • Study Type:Experimental Animal Study,
  • Source: 10.1038/s41598-018-35706-8
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