Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy

Author: mycolabadmin
2020-05-25
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Summary

This research examines how Turkey Tail mushroom (Trametes versicolor) can help fight cancer through its unique polysaccharide compounds. These compounds work in two main ways: by directly killing cancer cells and by boosting the body’s immune system to better fight cancer. The research shows promise for using these mushroom compounds alongside conventional cancer treatments to improve outcomes. Impacts on everyday life: • Provides a natural supplement option for cancer patients undergoing conventional treatment • Offers a potentially safer alternative to boost immune system function • Demonstrates how traditional medicines can be validated by modern science • Shows potential for developing new cancer treatment strategies • Highlights the importance of mushrooms as sources of beneficial compounds

Background

Cancer is the second leading cause of mortality worldwide, accounting for an estimated 9.6 million deaths in 2018. While chemotherapy remains a major control measure, medicinal mushrooms have emerged as potential adjuvants to conventional cancer therapies. Trametes versicolor (formerly known as Coriolus versicolor), commonly called Turkey Tail, is one of the most extensively studied medicinal mushrooms with a 2000-year history of use in traditional Chinese medicine.

Objective

This review aims to assess the anti-cancer properties of Trametes versicolor polysaccharides, particularly PSP and PSK, by examining their chemistry, pharmacology, and therapeutic potential through in vitro, in vivo, and clinical studies. The review focuses on both direct cytotoxicity against cancer cells and immunostimulatory effects.

Results

T. versicolor polysaccharides demonstrated direct cytotoxicity against various cancer cell lines, induced apoptosis, and showed cell cycle arrest effects at concentrations below 100 μg/mL in vitro. In vivo studies showed tumor size reduction and enhanced immune responses. Clinical trials revealed improved survival rates and enhanced immune parameters in cancer patients. The polysaccharides work through multiple mechanisms including TLR4 activation, enhanced cytokine production, and stimulation of immune cells including T-cells, B-cells, and natural killer cells.

Conclusion

T. versicolor polysaccharides exhibit significant anti-cancer potential through both direct cytotoxicity and immunostimulation. Their ability to enhance conventional cancer therapies, favorable safety profile, and multiple mechanisms of action support their use as adjuvant therapy in cancer treatment. The evidence suggests applications beyond just adjuvant therapy, though more research is needed on structural components and precise mechanisms of action.

Published in:Biomedicines,
Study Type:Review,
Source: 10.3390/biomedicines8050135