A Status Review of the Bioactive Activities of Tiger Milk Mushroom Lignosus rhinocerotis (Cooke) Ryvarden

Summary

The tiger milk mushroom (Lignosus rhinocerotis) is a traditional medicinal mushroom from Southeast Asia that shows promising health benefits. Research has shown it can help with various conditions including asthma, inflammation, and potentially cancer, while being safe for consumption. The mushroom works by modulating the immune system, fighting inflammation, and promoting nerve growth among other mechanisms. Impacts on everyday life: – Could provide a natural alternative for managing asthma symptoms – May help support immune system function and overall health – Shows potential as a natural anti-inflammatory supplement – Could be developed into natural medicines for various conditions – Represents a sustainable source of traditional medicine when cultivated

Background

Lignosus rhinocerotis is a polypore mushroom found in Malaysia and Southeast Asia, traditionally known as ‘tiger’s milk mushroom’. Its sclerotium has been highly sought after by native communities to stave off hunger, relieve cough and asthma, and provide stamina. The mushroom consists of a pileus (cap), stipe (stem), and sclerotium (tuber), with the sclerotium being the main medicinal component.

Objective

To provide a comprehensive review of the validated scientific investigations on L. rhinocerotis, including its cognitive function, neuroprotection, immune modulation, anti-asthmatic, anti-coagulation, anti-inflammatory, anti-microbial/anti-viral, anti-obesity, anti-cancer/anti-tumor, and antioxidant properties.

Results

The studies demonstrated that L. rhinocerotis possesses multiple therapeutic properties including anti-asthmatic effects through reduction of IgE and inflammatory cytokines, anti-coagulant and fibrinolytic activities, anti-inflammatory effects via NO and cytokine reduction, antimicrobial properties, anti-obesity effects, significant antioxidant capacity, anti-tumor activities against various cancer cell lines, anti-viral effects against dengue virus, immunomodulatory actions, and neuritogenic properties promoting nerve growth. Toxicology studies showed it was safe for consumption with no adverse effects.

Conclusion

L. rhinocerotis shows significant potential as an alternative natural medicine for managing various non-communicable diseases. The mushroom demonstrates multiple therapeutic properties that have been scientifically validated through various studies. However, more research is needed to identify specific bioactive compounds and their mechanisms of action, and additional human clinical trials are required to fully establish its therapeutic applications.
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