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Polysaccharides with Antioxidative and Antiaging Activities from Enzymatic-Extractable Mycelium by Agrocybe aegerita (Brig.) Sing

Summary

This research examined how compounds extracted from the mushroom Agrocybe aegerita could help prevent aging and its negative effects. The study found that these mushroom-derived substances have powerful antioxidant properties that can protect various organs from age-related damage. Impact on everyday life: – Could lead to development of natural anti-aging supplements – Provides scientific support for using mushrooms as functional foods – Offers potential natural alternatives to synthetic antioxidants – May help prevent age-related organ damage and diseases

Background

Aging is an inevitable natural phenomenon characterized by accumulation response for dysregulation of immunity, decline of functions, atrophy of tissues, and wrinkling of skin. Previous studies have shown aging is involved in many diseases including cancers, neurodegenerative diseases, and cardiovascular diseases. Oxidative damage from reactive oxygen species (ROS) can cause cumulative cellular and organic damage and play crucial roles in aging-induced skeletal muscle decline.

Objective

This study aimed to investigate the antioxidant, antiaging, and organ protective effects of water-extractable mycelium polysaccharides (MPS) and enzymic-extractable mycelium polysaccharides (En-MPS) from Agrocybe aegerita (Brig.) Sing in D-galactose-induced aging mice.

Results

En-MPS demonstrated stronger antioxidant activities in dose-dependent manners compared to MPS. Both En-MPS and MPS showed potential effects on antioxidation, antiaging, and organ protection by improving antioxidant enzyme activities, decreasing lipid peroxidation, and remitting lipid metabolism. The polysaccharides significantly increased SOD, CAT and T-AOC activities while decreasing MDA levels. Histopathological observations showed both polysaccharides could protect brain, liver and kidney tissues from D-galactose toxicity.

Conclusion

Both En-MPS and MPS from A. aegerita showed potential antioxidant, antiaging, and organic protective effects against D-galactose-induced aging toxicities. The differences in biological activity between MPS and En-MPS showed significant correlation to their purity. These polysaccharides could be exploited as natural functional foods for prevention and alleviation of aging and its complications.
  • Published in:Evidence-based Complementary and Alternative Medicine,
  • Study Type:Experimental Study,
  • Source: 10.1155/2018/1584647
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