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Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector

Summary

This research reviewed studies on how the reishi mushroom (Ganoderma lucidum) can protect against radiation damage. The studies showed that compounds from the mushroom could help protect cells and DNA from radiation injury in laboratory and animal experiments. While more research is needed before use in humans, this natural medicine shows promise as a potential radiation protector. Impacts on everyday life: • Could help protect people receiving medical radiation treatments • May benefit workers in radiation-exposed environments • Demonstrates the potential of natural medicines for modern medical applications • Provides scientific support for traditional uses of medicinal mushrooms • Could lead to development of safer radiation protection methods

Background

Ganoderma lucidum (reishi mushroom) has been used for millennia in traditional medicine and was recorded in the oldest Chinese herbal encyclopedia. It is a wood-degrading Basidiomycota fungus widely distributed in tropical and temperate regions. The mushroom has shown diverse therapeutic properties, including a radioprotective effect in its extracts and isolated polysaccharide components.

Objective

To systematically review and evaluate the radioprotective effects of Ganoderma lucidum through analysis of ex vivo, in vitro, and in vivo studies.

Results

From 1109 identified records, 15 full-text articles met inclusion criteria – including 3 ex vivo, 13 in vivo, and 4 in vitro studies. Ex vivo studies showed β-glucan from aqueous extracts protected human blood cells from radiation damage. In vivo studies demonstrated effectiveness of polysaccharides and triterpenes in mice exposed to γ-rays. In vitro plasmid studies showed reduction in radiation-induced DNA damage. No clinical trials were found testing G. lucidum as a radioprotector.

Conclusion

Evidence from experimental studies indicates G. lucidum extracts, particularly β-glucan polysaccharides and triterpenes, demonstrate radioprotective effects in cellular and animal models. However, further clinical research is needed before implementation as a radioprotector in humans since current dosing cannot be directly correlated to human use.
  • Published in:Nutrients,
  • Study Type:Systematic Review,
  • Source: 10.3390/nu12041143
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