Subcritical Water Extracts from Agaricus blazei Murrill’s Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor
- Author: mycolabadmin
- 2021-07-23
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Summary
This research investigated how extracts from the medicinal mushroom Agaricus blazei Murrill (ABM) could help fight cancer. The scientists found that using hot water under pressure to extract compounds from the mushroom’s root-like structure (mycelium) produced substances that could boost the immune system’s ability to fight cancer cells. This method is safer than traditional chemical extraction methods and could be more practical for large-scale production.
Impacts on everyday life:
• Provides a safer, more natural approach to cancer treatment
• Offers potential for new dietary supplements to support cancer therapy
• Demonstrates a more environmentally friendly way to produce medicinal mushroom extracts
• Could lead to more affordable cancer treatment options
• Shows promise for combining natural products with modern medicine
Background
Agaricus blazei Murrill (ABM) or Himematsutake is an edible and medicinal mushroom with known anticancer properties, though the mechanism remains unclear. Traditional extraction methods use basic or organic solvents that are hazardous for human health. The inhibition of immune checkpoint molecules and Axl receptor has emerged as an effective cancer therapy approach.
Objective
This study aimed to assess whether subcritical water extracts of ABM’s fruiting body or mycelium affect the expression of Axl and immune checkpoint molecules in lung cancer cells. The researchers also investigated if these extracts could enhance immune response through dendritic cell maturation.
Results
The subcritical water extracts from both ABM fruiting body and mycelium significantly inhibited the expression of immune checkpoint molecules and Axl compared to saline-treated cells. The hot water extract, subcritical water extract, and hot water extraction residue subcritical water extract from ABM mycelium significantly enhanced the expression of maturation markers in dendritic cells. The inhibitory effects were comparable to traditional alkaline extracts.
Conclusion
The subcritical water extract from ABM mycelium effectively decreases the expression of immune checkpoint molecules and Axl receptor tyrosine kinase in lung cancer cells while enhancing dendritic cell maturation markers. This suggests that subcritical water extract from ABM mycelium could be a promising therapeutic tool for stimulating immune response against cancer.
- Published in:Journal of Fungi,
- Study Type:Laboratory Research,
- Source: 10.3390/jof7080590