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The Anti-Fatigue and Sleep-Aiding Effects Vary Significantly Among Different Recipes Containing Ganoderma Lucidum Extracts

Summary

This research explored how different recipes containing Ganoderma lucidum (reishi mushroom) can help with either fatigue or sleep problems. Scientists found that different combinations of mushroom extracts had distinct effects – one formula helped improve physical endurance and reduce fatigue, while another helped people fall asleep faster and sleep longer. This is significant because it shows that natural mushroom-based supplements can be specifically formulated for different health needs. Impacts on everyday life: • Provides a natural alternative to chemical sleep aids and energy drinks • Offers potential solutions for people struggling with fatigue or sleep issues • Demonstrates that natural supplements can be customized for specific health needs • Shows promise for developing safer, non-addictive sleep and anti-fatigue supplements • Could help improve quality of life for people with sleep disorders or chronic fatigue

Background

In today’s fast-paced modern life, work-related stress, irregular eating habits and sleep patterns can lead to fatigue and insomnia, affecting approximately one-third of the global population. Fatigue is a complex physiological and biochemical process involving energy depletion, metabolite accumulation, and oxygen-free radical-induced lipid peroxidation. Sleep disorders and inability to combat fatigue can lead to multiple health risks, including depression and cancers.

Objective

This study aimed to investigate the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts, specifically examining two recipes: PGB (incorporating Ganoderma lucidum extract, broken Ganoderma lucidum spore powder, and Paecilomyces hepiali mycelium) and GBS (composed of Ganoderma lucidum extract, broken spore powder, and Ganoderma sinense powder).

Results

PGB treatment significantly prolonged exhaustion time in weight-bearing swimming (from 10.1 ± 0.5 min to 15.2 ± 1.3 min), increased glycogen levels in livers and muscles, and decreased serum lactic acid, urea nitrogen, and MDA levels. GBS treatment improved sleep quality, with shortened sleep latency (from 6.8 ± 0.7 min to 4.2 ± 0.4 min), extended sleep duration (from 88.3 ± 1.4 min to 152.5 ± 9.3 min), and decreased muscle MDA levels.

Conclusion

PGB, enriched with Ganoderma polysaccharides, exhibits notable anti-fatigue activity, while GBS, formulated with extracts from Ganoderma sinense and Ganoderma lucidum, demonstrates pronounced sleep-improving effects. These results indicate that Ganoderma lucidum-based recipes can effectively target either fatigue or sleep issues depending on the specific combination of compatible ingredients.
  • Published in:Heliyon,
  • Study Type:Experimental Animal Study,
  • Source: 10.1016/j.heliyon.2024.e30907
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