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Dietary Supplementation with Tolypocladium Sinense Mycelium Prevents Dyslipidemia Inflammation in High Fat Diet Mice by Modulation of Gut Microbiota

Summary

This research investigated how a fungal supplement derived from Chinese traditional medicine can help prevent obesity and its related health problems. The supplement works by improving the balance of beneficial bacteria in the gut and reducing inflammation in the body. Ways this research impacts everyday life: – Offers a potential natural supplement option for preventing weight gain and obesity – Demonstrates the importance of gut bacteria in maintaining healthy body weight – Provides scientific support for traditional medicine approaches to metabolic health – Suggests new strategies for managing cholesterol and blood lipid levels – Shows how dietary supplements can positively influence gut bacterial composition

Background

Obesity is a major global health concern associated with inflammation, hyperlipidemia, and gut dysbiosis. Tolypocladium sinense is a fungus isolated from Chinese caterpillar fungus with potential gut microbiota modulation effects. Prevention of obesity through dietary intervention is crucial for human health.

Objective

To evaluate the anti-obesity effects of lyophilized T. sinense mycelium (TSP) supplementation in a high-fat diet (HFD)-induced hyperlipidemia mouse model and investigate its mechanisms of action through gut microbiota modulation.

Results

TSP supplementation effectively alleviated inflammatory response and oxidative stress levels caused by obesity. It prevented obesity and suppressed dyslipidemia by regulating lipid metabolism genes in the liver. TSP prevented HFD-induced decline in short-chain fatty acid content and reversed diet-induced bacterial abundance changes. The treatment increased beneficial bacteria like Lactobacillus and Prevotella_9 while reducing obesity-associated bacteria. Correlation analysis showed these microbial changes were closely related to improvements in lipid metabolism and inflammatory parameters.

Conclusion

TSP supplementation demonstrates protective effects against HFD-induced obesity and hyperlipidemia by modulating gut microbiota composition, alleviating inflammatory response, and regulating hepatic lipid metabolism gene expression. The findings suggest TSP has therapeutic potential for treating obesity and related complications through its prebiotic effects.
  • Published in:Frontiers in Immunology,
  • Study Type:Experimental Animal Study,
  • Source: 10.3389/fimmu.2022.977528
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