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Psychedelic Drugs or Hallucinogens: Exploring Their Medicinal Potential

Summary

Psychedelic drugs like LSD and psilocybin are substances that alter perception and consciousness. Research shows they may help treat serious mental health conditions including depression, anxiety, and PTSD by affecting how the brain forms new connections. These substances are relatively safe compared to many legal drugs, and scientists believe they could revolutionize mental health treatment when used properly under medical supervision.

Background

Serotonergic hallucinogens, commonly known as psychedelics, have been historically used in religious and cultural rituals. Despite societal misconceptions, contemporary research increasingly recognizes their therapeutic potential beyond recreational use.

Objective

To conduct a comprehensive review of serotonergic hallucinogens and their potential therapeutic applications in treating neuropsychiatric disorders such as depression, PTSD, and anxiety.

Results

LSD and psilocybin demonstrated potent effects on serotonin receptors, particularly the 5-HT2A receptor. These substances showed therapeutic promise for depression, PTSD, anxiety, and potentially neurodegenerative conditions through their influence on neuroplasticity. Traditional psychedelics exhibited relatively low addiction risk compared to substances like alcohol.

Conclusion

Psychedelics represent promising therapeutic agents for neuropsychiatric disorders when administered under appropriate clinical conditions. A paradigm shift is needed from viewing these substances as recreational entities to recognizing their potential as therapeutic tools, requiring rigorous scientific investigation and open societal dialogue.
  • Published in:Cureus,
  • Study Type:Review,
  • Source: PMID: 38094517, DOI: 10.7759/cureus.48719
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