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Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences

Summary

This research shows that taking a specialized supplement containing natural plant compounds along with eating a Mediterranean diet can significantly help people with fatty liver disease. The supplement works by reducing harmful stress molecules in liver cells and calming down inflammation. After three months of treatment, patients showed improved liver health markers, better cholesterol levels, and improved blood sugar control. The study demonstrates that combining diet and targeted supplements is more effective than diet changes alone.

Background

Nonalcoholic fatty liver disease (NAFLD) is the major chronic liver disease and hepatic component of metabolic syndrome. Oxidative stress and inflammation are key mechanisms underlying NAFLD development. Recent evidence suggests that diet rich in antiinflammatory and antioxidant phytochemicals may be useful in treating NAFLD.

Objective

This study evaluated the effect of nutraceutical supplementation (NS) containing Leucoselect Phytosome, red yeast rice, monacolin K, polycosanols, and folic acid combined with Mediterranean hypocaloric diet (MHD) on hepatic steatosis indices and inflammation in adults with hyperlipidemia and NAFLD, using both clinical and in vitro approaches.

Results

After 3 months, only the combined MHD and NS treatment significantly reduced insulin resistance, hepatic steatosis indices, low-density lipoprotein cholesterol, and γ-glutamyl transferase. In vitro, the nutraceutical mixture decreased TNFα- and fatty acid-induced reactive oxygen species, modulated inflammatory response by lowering IL-6 and IL-1β while increasing IL-10, and demonstrated antiapoptotic effects.

Conclusion

Nutraceutical supplementation combined with Mediterranean hypocaloric diet represents a promising strategy for NAFLD management through its antiinflammatory and antioxidant properties. The synergistic effects of individual components are more efficacious than single compounds in counteracting oxidative stress and inflammation-induced damage in hepatocytes.
  • Published in:Molecular Nutrition & Food Research,
  • Study Type:Clinical Trial - Retrospective Observational Study with In Vitro Research,
  • Source: PMID: 40913543, DOI: 10.1002/mnfr.70207
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