Efficacy and safety of MT104, a dietary supplement based on Cuscuta seeds and heat‐killed probiotics, on cognitive function in patients with mild cognitive impairment: A 12‐week, multicenter, randomized, double‐blind, placebo‐controlled clinical trial

Summary

Researchers tested a dietary supplement called MT104 made from Cuscuta seeds and special probiotics to see if it could improve memory and thinking in people with mild cognitive impairment, an early stage before dementia develops. In a 12-week study with 200+ participants, those taking MT104 showed better memory recall and overall cognitive function compared to those taking a placebo. The supplement appeared to be safe with no serious side effects, suggesting it could be a helpful natural approach to slow the progression toward Alzheimer’s disease.

Background

Mild cognitive impairment (MCI) represents the symptomatic pre-dementia stage of Alzheimer’s disease. Given the increasing prevalence of AD and its socioeconomic burden, delaying the progression of MCI to AD is critical. Modulating the microbiota-gut-brain (MGB) axis has emerged as a promising therapeutic approach.

Objective

This study aimed to evaluate the efficacy and safety of MT104, a dietary supplement containing Cuscuta seeds and heat-killed probiotics, in regulating the MGB axis in patients with MCI.

Results

The mean changes in verbal memory function, as measured by SVLT delayed recall, showed clinically significant improvement in the MT104 group compared with the placebo group in both intention-to-treat and per-protocol groups. The global cognition, as measured by the K-MoCA, also significantly improved in the per-protocol group. Additionally, there were no significant findings regarding the safety profile of MT104.

Conclusion

MT104 improved memory performance and global cognition in patients with MCI without safety concerns. These findings support the potential of dietary therapeutic strategies to reduce the risk of progression from MCI to AD dementia. Further studies are needed to confirm these results and explore the long-term benefits of MT104.
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