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Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion’s Mane Extracts

Summary

Researchers tested three medicinal mushrooms (Maitake, Lion’s Mane, and Reishi) as ingredients in washing gels to improve their safety and effectiveness. The study found that these mushroom extracts reduced skin irritation, improved skin moisturization, and boosted antioxidant protection better than gels without them. Maitake extract performed particularly well, showing the strongest antioxidant properties. These findings suggest mushroom extracts could be valuable natural alternatives in everyday skincare products.

Background

Natural cosmetics are increasingly popular as consumers seek alternatives to synthetic ingredients. Mushroom extracts contain bioactive compounds with antioxidant, anti-inflammatory, and antimicrobial properties, making them valuable for cosmetic applications. However, mushroom-based cosmetics are less widely studied than plant-based alternatives.

Objective

To investigate the cosmetic properties and safety of water extracts from three medicinal mushrooms (Reishi, Maitake, and Lion’s Mane) when incorporated into model washing gels. The study evaluated antioxidant properties, bioactive content, cytotoxicity, and effects on skin parameters including hydration, pH, and transepidermal water loss.

Results

Maitake extract showed the highest antioxidant activity and bioactive compound content (183.75 µg GAE/g dry weight of phenolics and 38.38 µg QE/g dry weight of flavonoids). All extracts reduced intracellular ROS production in skin cells. Addition of mushroom extracts to washing gels reduced irritant potential by 20-25%, improved skin hydration (350% increase for Reishi at 3h), reduced TEWL by 7-11%, and maintained physiological pH better than base formula.

Conclusion

Mushroom extracts, particularly Maitake, Lion’s Mane, and Reishi, demonstrate valuable cosmetic properties with improved safety profiles when incorporated into washing gels. These extracts reduce the irritant effects of surfactants while providing antioxidant benefits and improving skin hydration, making them promising natural ingredients for cleansing cosmetics.
  • Published in:Molecules,
  • Study Type:Experimental/In Vitro Study,
  • Source: PMID: 36014338, DOI: 10.3390/molecules27165090
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