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Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model

Summary

Oyster and white button mushrooms may help lower cholesterol and protect against heart disease. In a study using rats with high cholesterol, mushroom extracts reduced harmful cholesterol levels and improved the body’s natural defense against oxidative damage. These common, affordable mushrooms contain beneficial compounds that could be incorporated into diets as a natural way to support heart health and manage cholesterol.

Background

Hypercholesterolemia and dyslipidemia are major risk factors for cardiovascular diseases globally. Edible mushrooms contain bioactive compounds including phytosterols, polyphenols, and antioxidants that may have beneficial effects on cholesterol levels and oxidative stress.

Objective

To explore and compare the hypolipidemic and antioxidant potential of oyster (Pleurotus ostreatus) and white button (Agaricus bisporus) mushroom extracts using hypercholesterolemic rat models.

Results

Treatment groups receiving 200 mg oyster and white button mushroom extracts showed 15%, 34%, 22% reductions in total cholesterol, triglycerides, and vLDL respectively, with 22% improvement in HDL. Mushroom extracts reduced oxidative stress markers and improved antioxidant enzyme activity (SOD and GPx). Liver histopathology showed dose-dependent improvement toward normal architecture.

Conclusion

Oyster and white button mushroom extracts demonstrated significant hypolipidemic and antioxidant potential in hypercholesterolemic rats. These natural interventions show promise for managing dyslipidemia and oxidative stress-related conditions, supporting their potential therapeutic application.
  • Published in:Foods,
  • Study Type:Animal Model Study,
  • Source: 10.3390/foods13050709
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