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Biologically active secondary metabolites from white-rot fungi

Summary

White-rot fungi are special mushrooms that can break down wood and produce unique chemical compounds with amazing health benefits. These compounds have been found to fight cancer, kill harmful bacteria, reduce inflammation, and protect nerve cells. Scientists are excited about using these natural fungal compounds to create new medicines and treat various diseases in the future.

Background

White-rot fungi are unique microorganisms capable of decomposing all wood components and play important roles in carbon and nitrogen cycles. These fungi produce various bioactive secondary metabolites alongside ligninolytic enzymes, which exhibit antimicrobial and anticancer properties of potential pharmaceutical interest.

Objective

To review secondary metabolites produced by white-rot fungi and their diverse bioactive properties, considering their untapped potential for pharmaceutical and industrial applications.

Results

White-rot fungi produce diverse bioactive compounds including terpenoids, polyphenols, sterols, flavonoids, alkaloids, quinolones, anthraquinones, and lactones with antimicrobial, anticancer, antioxidative, anti-inflammatory, and neuroprotective properties.

Conclusion

White-rot fungi represent a significant untapped source of biologically active secondary metabolites with extensive potential applications in pharmaceutical development, agriculture, food industry, and bioremediation technologies.
  • Published in:Frontiers in Chemistry,
  • Study Type:Review,
  • Source: PMID: 38545465, DOI: 10.3389/fchem.2024.1363354
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